منابع مشابه
DC-SIGN and immunoregulation.
Dendritic cells (DCs) are known to be the most powerful professional antigen-presenting cells so far. It could activate primary immune response, and also downregulate immune response. DCs have a unique character of immunoregulation. DC-SIGN, a molecule designated as CD209, is one member of the C-type lectin superfamily. It is not only a pattern recognition receptor but implicated in immunoregul...
متن کاملThe simultaneous triggering of DCIR and DC-SIGN hampers DC-SIGN-mediated endo-lysosomal routing
Several C-type lectins (CLRs) are expressed on dendritic cells (DCs). CLRs are carbohydrate-specific receptors involved in the recognition of glycosylated antigens. The interaction of CLRs with their ligands facilitates antigen internalization and can induce signaling or modulate TLR-induced signaling responses. Here, we investigated the internalization characteristics of four different CLRs: M...
متن کاملRelevance of DC-SIGN in DC-induced T cell proliferation.
The role of dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) in DC-T cell communication was assessed by analyzing the effect of DC-SIGN-blocking mAb in MLR. The results show that the degree of inhibition by DC-SIGN and LFA-1 mAb depends on the magnitude of the MLR and the maturation status of the DC. Addition of DC-SIGN mAb at several time-points during MLR showed that DC-SIGN is i...
متن کاملDC-SIGN (dendritic cell-specific ICAM-grabbing non-integrin) and DC-SIGN-related (DC-SIGNR): friend or foe?
C-type lectins are calcium-dependent carbohydrate-binding proteins with a wide range of biological functions, many of which are related to immunity. DC-SIGN (dendritic cell-specific ICAM-grabbing non-integrin, where ICAM is intercellular adhesion molecule) is a recently described mannose-specific C-type lectin expressed by dendritic cells. Dendritic cells are potent antigen-presenting cells cap...
متن کاملQuinoxalinone Inhibitors of the Lectin DC-SIGN.
The C-type lectin dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) can serve as a docking site for pathogens on the surface of dendritic cells. Pathogen binding to DC-SIGN can have diverse consequences for the host. DC-SIGN can facilitate HIV-1 dissemination, but the interaction of Mycobacterium tuberculosis with DC-SIGN is important for host immunity. Th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell
سال: 2000
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)80684-4